TarFisDock   [Target Fishing Dock]

 
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TarFisDock : a web server for identifying drug targets with docking approach

TarFisDock Server is restarted on 08/30/2014!

Given a small molecule which can be drug, drug candidate, natural product, or new synthetic compound, TarFisDock docks it into the protein targets in PDTD (Potential Drug Target Database), and outputs the top 2%, 5% or 10% candidates ranked by the energy score, including their binding conformations and a table of the related target information.

The server is freely accessible for anonymous user. And one user's result is protected from being retrieved by another. However users are encouraged to fill in a very simple registration form for better safety and convenience.

Now submit your molecular structure(in mol2 format) by clicking

  • References

    1. Honglin Li, Zhenting Gao, Ling Kang, Hailei Zhang, Kun Yang, Kunqian Yu, Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Jianhua Shen, Xicheng Wang & Hualiang Jiang. TarFisDock: a web server for identifying drug targets with docking approach. Nucl. Acids Res. 34, W219-224 (2006) URL

    2. Zhenting Gao, Honglin Li, Hailei Zhang, Xiaofeng Liu, Ling Kang, Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Xicheng Wang & Hualiang Jiang. PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics 9:104 (2008) URL


  • Applications

    1. J. Cai, C. Han, T. Hu, J. Zhang, D. Wu, F. Wang, Y. Liu, J. Ding, K. Chen, J. Yue, X. Shen & H. Jiang. Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: Reverse docking, enzymatic assay, and x-ray crystallography validation. Protein Sci (2006) URL
    2. Jeong CH, Bode AM, Pugliese A, Cho YY, Kim HG, Shim JH, Jeon YJ, Li H, Jiang H, Dong Z. [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res., 2009. 69(13) : 5584-91 URL

  • Comments/Questions

    Feel free to send comments or questions about the TarFisDock and PDTD. Registered user please post on our forum.

 

News:  TarFisDock is free for registration!
   

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Current Server Time: 2017-05-25 10:20pm |Job queue status
Drug Discovery and Design Center(DDDC), SIMM, CAS
State Key Laboratory of Structural Analysis for Industrial Equipment, DUT