Mevinolin is one of the earlier statin drugs which is effective for the treatment of hypercholesterolemia, as an inhibitor
of the HMG-CoA reductase. The transformations of mevinolin in acidic alcohol( such as ethanol, methanol and
isopropanol ) solutions caused by solvent effects were revealed in the present article. The solvates, that is, mevinolinic
methyl ester, mevinolinic ethyl ester and mevinolinic isopropyl ester, were identified by LUPDA and LUMS. The
kinetics parameters of the transformations caused by solvent effects, such as the observed rate constant of mevinolin
(k,) , the maximum concentration( c,,,") , and its corresponding maximum time( t,, , time for the acid form to reach
the maximum concentration) of mevinolinic acid, are discussed. The influencing factors, such as the kind of solvents,
the acidic concentration, the initial mevinolin concentration, and the water content as well as temperature were
investigated. Two kinds of comparative reactions, hydrolysis and alcoholysis , of mevinolin in solution were studied.
This detailed study on the kinetics of mevinolin transformations is valuable and meaningful for the purification, preparation,
injection manufacturing, extraction, storage, etc. , of mevinolin or other similar compounds. This work provides
useful information for the quality control of mevinolin and mevinolin-like drugs as well.