Gold-Catalyzed One-Pot Cascade Construction of Highly Functionalized Pyrrolo[1,2-a]quinolin-1(2H)-ones
An efficient protocol was developed for the synthesis of fused heterocyclic multiring compounds
pyrrolo[1,2-a]quinolin-1(2H)-ones via a AuBr3/AgSbF6-catalyzed cascade transformation. Significantly,
the strategy affords a straightforward and efficient approach to construction of tricyclic
lactammolecular architectures in which two newC-Cbonds and one newC-Nbond are formed in a
one-pot synthetic operation from simple starting materials. Moreover, a broad spectrum of
substrates can participate in the process effectively to produce the desired products in good yields
and with excellent regio- and chemoselectivities.