Abstract Cyclophilin A(CypA)is a member of cyclophilins£¬a family of the highly homologous poptidyl pmlyl c£Æs”Ŗ
trans isomerases(PPIases)£¬which can bind to eyclosporin A(CsA)£®CypA plays critical roles in various biological
proc~ses£¬including protein folding£¬assembly£¬transportation£¬regulation of neuron growth and HIV replication£®in the
article£¬the whole development of natural product leads£¬pepfide analogue inhibitors and organic synthesized compounds
of CypA inhibitors was summarized and the research progress of CypA was reviewed£®