Amination of arylboronic acids is one of the most
important reactions in the synthesis of essential intermediates
and targets of numerous pharmaceutical agents, agrochemicals,
natural products, and industrial materials containing the
N-aryl moiety.1 One of the traditional methods to create the
C-N bond is the transition-metal-catalyzed arylation of
nucleophiles with aryl halides, that is, the Ullmann or
Goldberg condensations.2 Recently, significant progress has
been achieved in C-N bond formation; for example,
Ullmann coupling has led to the emergence of several
protocols based on copper or iron-copper catalysis.3 Chan
and Lam4 reported the preparation of C-N bonds via Cumediated
coupling of amines with arylboronic acids under
milder conditions, where arylboronic acids are used as
arylating agents instead of aryl halides.5 Although these
methods are highly effective, there is still much room for
improvement, for example, these methods usually require
high temperatures, long reaction times, and complex ligands,
and some of them suffer from a relatively narrow scope of
substrates, especially for aniline derivatives.