An efficient and effective microwave-assisted cross-coupling
of terminal alkynes with various aryl chlorides including
sterically hindered, electron-rich, electron-neutral, and electron-
deficient aryl chloride is developed. It proceeds faster and
generally gives good to excellent yields and also can be
extended successfully to the Suzuki coupling and Buchwald-
Hartwig amination, as well as the Heck coupling with inert
aryl chlorides. The short reaction times and simple reaction
conditions coupling with a broad substrate scope render this
method particularly attractive for the efficient preparation
of biologically and medicinally interesting molecules.