Abstract¡ªTreatment of methyl 5-acetamido-2,4,7,8,9-penta-O-acetyl-3,5-dideoxy-b-L-glycero-D-galacto-2-nonulopyranosidonate
(1) with cyclic secondary amines in pyridine at room temperature for 24 h afforded unusual products (2a¨Cg). Related experiments
were carried out to explain the formation of 4-amination and 2-O-deacetylation of peracetylated sialic acid derivatives (2a¨Cg). This
reaction may provide a new strategy for the preparation of Zanamivir analogues as neuraminidase inhibitors for anti-H5N1 subtype
of avian influenza virus (AIV).