Discovery of novel inhibitors of 11b-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling
Abstract—11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) is a potential target for treatment of diabetes and metabolic syndrome.
Docking and pharmacophore modeling have been used to discover novel inhibitors of 11b-HSD1. Several compounds, with
large structural diversity and good potency against 11b-HSD1, have been found and their potency was determined by the enzyme
assay. New scaffolds of 11b-HSD1 inhibitors are also reported.