Gold- and Silver-Catalyzed Intramolecular Hydroamination of Terminal Alkynes: Water-Triggered Chemo- and Regioselective Synthesis of Fused Tricyclic Xanthines

Abstract: A simple, convenient and green synthetic
approach to diverse fused tricyclic xanthines has
been developed via gold(I) complex-catalyzed intramolecular
hydroamination or silver(I)-catalyzed isomerization-
hydroamination of terminal alkynes
under microwave irradiation in water. The first synthesis
of N9-annelated xanthines has also been reported.
Keywords: gold; hydroamination; silver; terminal
alkynes; xanthines