Abstract We have developed the first operationally
simple and environmentally benign protocol for the aqueous
asymmetric Michael addition reaction of chiral nickel(
II) glycinate with nitroalkenes. The reactions proceeded
smoothly in the presence of TBAB (tetrabutyl ammonium
bromide) in neat water at room temperature and provided
good yields of b-substituted a,c-diaminobutyric acid
derivatives with excellent diastereoselectivities.