Abstract: A highly efficient organocatalyzed Michael
addition of 2-oxindole-3-carboxylate esters to
nitroolefins using a Cinchona alkaloid-thiourea and
an achiral Brønsted acid as cooperative organocatalysts
is reproted that affords significantly improved
enantioselectivity and diastereoselectivity. It also
provides an efficient approach to the synthesis of
spirooxindole derivatives with high enantioselectivity.