Silver and Gold-mediated Intramolecular Cyclization to Substituted Tetracyclic Isoquinolizinium Hexafluorostilbates

Fang Liu, Xiao Ding, Lei Zhang, Linxiang Zhao, Hualiang Jiang, and Hong Liu

A convenient route for the synthesis of various charged tetracyclic isoquinolizinium hexafluorostilbates
was developed using AgSbF6/AuCl(PPh3) for the intramolecular addition of amine to alkyne.
The described process is tolerant of a variety of functional groups and broadens the diversity of
substrates with the use of 8-substituted tetracyclic isoquinolizinium salts.