First Reaction of a Chiral Gly-Ni(II)-Complex on Water

Guannan Liu, Yu Zhou, Xiao Ding, Jiang Wang, Hualiang Jiang, Hong Liu

The amination of a chiral Ni(II) complex as a model reaction was studied to develop a highly practical, efficient,
and stereospecific approach for Ni(II) complex reactions in an aqueous phase. A convenient and clean
water-mediated reaction of the Ni(II) complex has been reached, and a broad spectrum of substrates could
participate in the process effectively to produce desired products in good yields and excellent diastereoselectivities.
Significantly, it is the first report of chiral gly-Ni(II) complex reaction in aqueous media.
Keywords Ni(II) complex, asymmetric reaction, water chemistry