One-pot Approach for C-C Bond Formation through Ru-amino Complex Catalyzed Tandem Aldol Reaction/Hydrogenation

Haifeng Sun, Deju Ye, Hualiang Jiang, Kaixian Chen, and Hong Liu

A one-pot novel and efficient approach was developed for the a-alkylation of various nitriles with carbony1 compounds using ruthenium-amido complex catalyst 1.The C-C bond was formed through aldol reaction followed by hydrogenation with triethylamine-formic acid (TEAF) and 1. Moderate to high yields were obtained, and a variety of functional groups were tolearted, including nitro and chloro groups, and a furan ring.