Gold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/PyridoACHTUNGTRENUNG[2,1-b]benzo[d]ACHTUNGTRENUNG[1,3]oxazin- 1-ones

A highly efficient method has been developed
for the one-pot synthesis of multi-ring heterocyclic
compounds such as pyrrolo-/pyridoACHTUNGTRENUNG[2,1-
b]benzo[d]ACHTUNGTRENUNG[1,3]oxazin-1-ones from o-aminobenzyl
alcohols via a gold(I)-catalyzed tandem coupling/
cyclization reaction. Significantly, the strategy presents
a straightforward and efficient approach to
construct novel tricyclic or polycyclic molecular architectures
in which two new CN bonds and one
CO bond are formed in a one-pot reaction operation
from two simple starting materials. Moreover,
a broad spectrum of substrates can participate in
the process effectively to produce the desired products
in good yields.