PDTD [Potential Drug Target Database]

 

The possible binding proteins of Vitamin E

It was reported that Vitamin E may interact with multiple target proteins. Indeed, twelve targets for Vitamin E have already been reported (13), eight (12 entries) of these experimentally verified targets fall into the top 10% candidates picked up from the PDTD by the TarFisDock program.

 

Table 1. The top 10% candidates of Vitamin E binding proteins derived by TarFisDock
RANK PDB_ID ENERGY SCORE TARGET NAME

3

1K3Y

-34.19

Glutathione Transferase A1-1

8

1DHT

-31.91

Estrogenic 17-Beta Hydroxysteroid Dehydrogenase

11

1VXR

-31

Acetylcholinesterase

16

2NSE

-30.53

Nitric Oxide Synthase

22

1M9M

-30.08

Nitric Oxide Synthase

26

1HDC

-29.91

3-alpha-hydroxysteroid Dehydrogenase

46

1ADC

-28.53

Alcohol Dehydrogenase

52

1HDC

-28.31

3-alpha-hydroxysteroid Dehydrogenase

54

1MCB

-28.25

Immunoglobulin lambda Light Chain Dimer; Immunoglobulin lambda Light Chain Dimer (Mcg)

63

1MCJ

-27.92

Immunoglobulin lambda Light Chain Dimer (Mcg)

92

2ACS

-27.04

Aldose Reductase

96

1GPN

-26.95

Acetylcholinesterase

* Targets highlighted by blue have been experimentally verified as listed in Table 2.

Table 2. The potential binding proteins of vitamin E published in literatures
Known Targets of Vitamin E References
Glutathione S-transferase (1)
Acetylcholinesterase (2)
17 β-hydroxysteroid dehydrogen (3)
Alcohol dehydrogenase (4)
Glutathione synthetase (5)
D-amino acid oxidase (6)
Guanylyl cyclase (7)
Protaglandin endoperoxide synthase (8)
Nitric oxide synthase (9)
Aldose reductase (10)
Immunoglobulin (11)
Purine nucleoside phosphorylase (12)
*These targets were summarized by Chen et al.(13)
References:

1.   Arita, M., et al., FEBS Lett, 1998. 436(3): p. 424-6.
2.   Chelliah, J., J.D. Smith, and M.W. Fariss, Biochim Biophys Acta, 1994. 1206(1): p. 17-26.
3.   Reddy, G.P., et al., Int J Androl, 1993. 16(3): p. 227-33.
4.   Tyopponen, J.T. and K.O. Lindros, Int J Vitam Nutr Res, 1986. 56(3): p. 241-5.
5.   Makar, T.K., et al., J Neurochem, 1994. 62(1): p. 45-53.
6.   Suga, T., et al., Biochim Biophys Acta, 1984. 794(2): p. 218-24.
7.   Sobolev, A.S., V.V. Tertov, and S.D. Rybalkin, Biokhimiia, 1982. 47(8): p. 1251-61.
8.   Greenberg-Levy, S.H., P. Budowski, and S. Grossman, Int J Biochem, 1993. 25(3): p. 403-9.
9.   Newaz, M.A., et al., Am J Hypertens, 1999. 12(8 Pt 1): p. 839-44.
10. Libondi, T., et al., Ophthalmic Res, 1985. 17(1): p. 42-8.
11. Reddy, P.G., et al., J Dairy Sci, 1986. 69(1): p. 164-71.
12. Bailey, S.M. and L.A. Reinke, Free Radic Res, 2000. 32(6): p. 497-506.
13. Chen, Y.Z. and D.G. Zhi, Proteins, 2001. 43(2): p. 217-26.